Cytokines Induce Monkey Neural Stem Cell Differentiation through Notch Signaling.
作者： Min Wang , Liming Yu , Lu-Ying Zhu , Hua He , Jie Ren
DOI: 10.1155/2020/1308526
关键词:
摘要: The mammalian central nervous system (CNS) has a limited ability to renew the damaged cells after brain or spinal cord injury whether it is nonhuman primates like monkeys humans. Transplantation of neural stem (NSCs) potential therapy for CNS injuries due their pluripotency and differentiation abilities. Cytokines play an important role in development repair injuries. However, detailed cytokine signaling response monkey rarely studied. In our previous research, we isolated NSCs from adult found effects cytokines on NSCs. Now, further analyzed regulation mechanisms proliferation such as bone morphogenic protein 4 (BMP4), BMP4/leukaemia inhibitory factor (LIF), retinoic acid (RA)/Forskolin. data showed that BMP4 inhibited cell arrest, but did not affect stemness BMP4/LIF promoted astrocyte-like NSCs, RA/forskolin induced neuronal NSC by regulating Notch signaling. These results provide some theoretical evidence regenerative medicine.
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