Clinical aspects and epidemiology of HPV infections

摘要: Abstract Over the past 15 years we have watched unfolding of an enormous volume information regarding HPV infections. Elaboration incredible genetic diversity these viruses has been important to development laboratory tools for epidemiological investigations and will facilitate future direction studies targeting specific molecular mechanisms disease. Through use tools, determined be a necessary but not sufficient etiologic agent in cervical cancer other cancers anogenital tract. The duration incident genital infections partially established this demonstrates that most detectable are transient. Recent observations second peak prevalence older women suggests possibility at least some women, may lay dormant undetectable levels subsequently become reactivated. potential experience reactivation latent infections, which accompanied by disease, requires further investigation. Current dogma concerning long-term natural history awaits clarification studies. Furthermore, remain appropriately characterize processes within host cell critical study immune responses Research-grade PCR-based tests continue ongoing better define incidence various anatomic sites. Of particular interest elaboration extragenital In regard, contribution HPVs skin outcomes is likely intensive area study. assays such as HC2 large randomized clinical trials testing viable option management ASCUS Pap smears. Further applications types testing, including routine screening, research. examine quantities or genomes messages currently underway. Probably exciting clinically relevant decade implementation prophylactic vaccines. To date targeted If vaccines can prevent infection CIN, maintenance vaccine immunity need evaluated establishment any impact on HPV-associated invasive one two decades following widespread implementation. Many individuals research groups participated contributing understanding epidemiology As with decades, rich discovery all.