Cell-based gene therapy for the pulmonary system

作者: Duncan J. Stewart

DOI:

关键词:

摘要: Cell-based gene transfer is effected by administering transfected cells containing an expressible transgene coding for angiogenic factor or other therapeutic factor, into the pulmonary circulation of a patient, where express and secrete expression products to act locally at site expression, in some cases be conveyed patient's body organs. The process especially useful treatment hypertension means expressed factors. Also provided use factors, delivered than cell-based transfer, treating hypertension.

参考文章(64)
Y. Tsurumi, S. Takeshita, J. F. Symes, M. Silver, D. Chen, M. Kearney, J. Yang, J. M. Isner, Treatment of acute limb ischemia by intramuscular injection of vascular endothelial growth factor gene. Circulation. ,vol. 96, ,(1997)
R Morishita, I Kida, T Ogihara, A new medical treatment for thrombosis by genetic engineering Nihon rinsho. Japanese journal of clinical medicine. ,vol. 57, pp. 1519- 1525 ,(1999)
T. Di Perri, Patrizia Blardi, L. Volpi, A. De Lalla, Stimulation of endogenous adenosine release by oral administration of quercetin and resveratrol in man. Drugs Under Experimental and Clinical Research. ,vol. 25, pp. 105- 110 ,(1999)
Uwe Junker, James J. Moon, Creton S. Kalfoglou, Irena Sniecinski, Stephen J. Forman, John A. Zaia, Hideto Kaneshima, Ernst Böhnlein, Hematopoietic Potential and Retroviral Transduction of CD34+Thy-1+ Peripheral Blood Stem Cells From Asymptomatic Human Immunodeficiency Virus Type-1–Infected Individuals Mobilized With Granulocyte Colony-Stimulating Factor Blood. ,vol. 89, pp. 4299- 4306 ,(1997) , 10.1182/BLOOD.V89.12.4299
Christoph Kalka, Tomono Takahashi, Harushika Masuda, Takayuki Asahara, Jeffrey M. Isner, VASKULARER ENDOTHELIALER WACHSTUMSFAKTOR (VEGF) : THERAPEUTISCHE ANGIOGENESE UND VASKULOGENESE IN DER BEHANDLUNG KARDIOVASKULARER ERKRANKUNGEN Medizinische Klinik. ,vol. 94, pp. 193- 201 ,(1999) , 10.1007/BF03044854
Ian D. Dube, Suzanne Kamel-Reid, Method and product of gene transfer into cells ,(1993)
Edith Tzeng, Larry L. Shears, Paul D. Robbins, Bruce R. Pitt, David A. Geller, Simon C. Watkins, Richard L. Simmons, Timothy R. Billiar, Vascular Gene Transfer of the Human Inducible Nitric Oxide Synthase: Characterization of Activity and Effects on Myointimal Hyperplasia Molecular Medicine. ,vol. 2, pp. 211- 225 ,(1996) , 10.1007/BF03401618
F. Mazurier, F. Moreau-Gaudry, S. Salesse, C. Barbot, C. Ged, J. Reiffers, H. de Verneuil, Gene transfer of the uroporphyrinogen III synthase cDNA into haematopoietic progenitor cells in view of a future gene therapy in congenital erythropoietic porphyria Journal of Inherited Metabolic Disease. ,vol. 20, pp. 247- 257 ,(1997) , 10.1023/A:1005365008147
Michael J. McCluskie, Cynthia L. Brazolot Millan, Robert A. Gramzinski, Harriet L. Robinson, Joseph C. Santoro, James T. Fuller, Georg Widera, Joel R. Haynes, Robert H. Purcell, Heather L. Davis, Route and method of delivery of DNA vaccine influence immune responses in mice and non-human primates. Molecular Medicine. ,vol. 5, pp. 287- 300 ,(1999) , 10.1007/BF03402065