Exposure to inhibitors of the renin-angiotensin system is a major independent risk factor for acute renal failure induced by sucrose-containing intravenous immunoglobulins: a case-control study.

摘要: Purpose Risk factors for intravenous immunoglobulin-induced renal failure (IVIg-RF) were suspected from case series studies. This study was aimed at quantifying the risk of IVIg-RF associated with exposure to drugs that modify intrarenal hemodynamics. Methods We conducted a case–control in French Pharmacovigilance Database (FPVD). Adult cases registered FPVD 1996 2009 reviewed. Controls patients included another IVIg adverse effect. matched sucrose content preparation, year event and age. The predictors angiotensin-converting enzyme inhibitors (ACE-I), angiotensin receptor antagonists (ARA), diuretics, age, gender weight, delivered dose infusion duration, chronic kidney disease, hypertension diabetes mellitus. Acute defined as calculated creatinine clearance less than 60 mL/min and, (i) more 50% increase serum creatinine, (ii) an indication oligo-anuria or (iii) requirement dialysis. Results We selected 71 controls. Forty-nine percent required transient hemodialysis. In final multivariate model, ACE-I and/or ARA sole independent predictor (OR = 7.9, 95%CI = 1.3–49.2). There interaction between ‘diabetes mellitus’ (OR = 7.7, 95%CI = 2.3–25.5) ‘chronic disease’ (OR = 13.0, 95%CI = 3.1–54.7), both being strong univariate models (p < 0.001). Chronic factor hemodialysis. Conclusions Temporary interruption may be considered time infusion. Copyright © 2011 John Wiley & Sons, Ltd.