Hepatotoxicity of salicylates in monolayer cell cultures.
作者： Keith G. Tolman , P. Peterson , P. Gray , Samuel P. Hammar
DOI: 10.1016/0016-5085(78)90797-7
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摘要: Abstract The influence of graded doses sodium salicylate on rat liver cells cultured in monolayers was assessed by measuring lactic dehydrogenase activity a culture media after incubation. Morphological alterations were studied electron microscopy. different albumin concentrations the toxicity also evaluated. Lactic rose with increasing up to 40 mg per dl. High associated reduced toxicity. These findings suggest that salicylate-induced hepatic injury is dose related and may be influenced serum levels.
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sci-hub.se 参考文章(22)
C. H. MIELKE, M. M. KANESHIRO, I. A. MAHER, J. M. WEINER, S. I. RAPAPORT, The Standardized Normal Ivy Bleeding Time and Its Prolongation by Aspirin Blood. ,vol. 34, pp. 204- 215 ,(1969) , 10.1182/BLOOD.V34.2.204.204
L. Lasagna, L. Lasagna, J. Bianchine, J. Bianchine, D. Shoeman, D. Shoeman, C.A. Dujovne, C.A. Dujovne, Experimental bases for the different hepatotoxicity of erythromycin preparations in man Journal of Laboratory and Clinical Medicine. ,vol. 79, pp. 832- 844 ,(1972) , 10.5555/URI:PII:0022214372900534
Balu H. Athreya, Glenda Moser, Henry S. Cecil, Allen R. Myers, Aspirin-induced hepatotoxicity in juvenile rheumatoid arthritis. A prospective study. Arthritis & Rheumatism. ,vol. 18, pp. 347- 352 ,(1975) , 10.1002/ART.1780180409
Robert R Rich, John S Johnson, Salicylate hepatotoxicity in patients with juvenile rheumatoid arthritis Arthritis & Rheumatism. ,vol. 16, pp. 1- 9 ,(1973) , 10.1002/ART.1780160102
T Iancu, Serum transaminases and salicylate therapy. BMJ. ,vol. 2, pp. 167- 167 ,(1972) , 10.1136/BMJ.2.5806.167
WILLIAM E. SEAMAN, Aspirin-Induced Hepatotoxicity in Patients with Systemic Lupus Erythematosus Annals of Internal Medicine. ,vol. 80, pp. 1- 8 ,(1974) , 10.7326/0003-4819-80-1-1
A. S. Russell, R. A. Sturge, M. A. Smith, Serum Transaminases during Salicylate Therapy BMJ. ,vol. 2, pp. 428- 429 ,(1971) , 10.1136/BMJ.2.5759.428
M. N. Berry, D. S. Friend, HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS: A Biochemical and Fine Structural Study Journal of Cell Biology. ,vol. 43, pp. 506- 520 ,(1969) , 10.1083/JCB.43.3.506
S. Madsen, A. A. Drivsholm, The influence of treatment with sodium salicylate on the serum glutamic oxalacetic transaminase activity. Scandinavian Journal of Clinical & Laboratory Investigation. ,vol. 13, pp. 442- 446 ,(1961) , 10.1080/00365516109137309
Balu H. Athreya, Aspirin-induced abnormalities of liver function. JAMA Pediatrics. ,vol. 126, pp. 638- 641 ,(1973) , 10.1001/ARCHPEDI.1973.02110190510010