Retraction Note to: MicroRNA-216b is Down-Regulated in Human Gastric Adenocarcinoma and Inhibits Proliferation and Cell Cycle Progression by Targeting Oncogene HDAC8.

摘要: Accumulating evidence indicates that micro (mi)RNAs play a critical role in carcinogenesis and cancer progression; however, their the tumorigenesis of gastric adenocarcinoma remains unclear so present study investigated this (GC) tissues cell lines. Human GC specimens (n = 57) patient-paired non-cancerous were obtained from patients at First Affiliated Hospital, Henan University Science Technology. The AGS GC9811 lines also used. Expression levels miR-216b HDAC8 examined by quantitative real-time PCR expression was Western blotting immunohistochemistry assay. cycle progression determined FACS. MiR-216b inhibitor, mimics, siRNA-HDAC8 transfections performed to loss gain function. We reported significantly decreased clinical compared with paired tissues. observed significant down-regulation (p < 0.0001). introduction suppressed proliferation targeting HDAC8, an oncogene shown promote malignant tumor development potential binding site its 3′ untranslated region. be increased (p < 0.0001) controls. Moreover, inhibition control groups (22 % ± 1.6 % vs 34 % ± 2.1), indicating may function as GC. Furthermore, negatively correlated (p < 0.0001), while positively outcome Our data suggest functions suppressor human by, least partially, HDAC8.