FAILURE OF PENICILLIN TO ERADICATE GROUP A STREPTOCOCCI DURING AN OUTBREAK OF PHARYNGITIS
作者： ArturoS Gastanaduy , BarbaraB Huwe , EdwardL Kaplan , Carolyn Mckay , LewisW Wannamaker
DOI: 10.1016/S0140-6736(80)91832-2
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摘要: In an outbreak of group A streptococcal pharyngitis in a semi-closed community, 42 (25%) 169 courses antibiotic therapy failed to eradicate the organism. 16 (19%) 85 individuals treated with intramuscular benzathine penicillin G and 9 47 patients oral (penicillin V or erythromycin) continued harbour same serotype streptococcus. 12 (48%) 25 persons remained treatment failures after re-treatment; even third course 5 (42%) still harboured Neither resistance epidemic strain nor reacquisition organism from contacts could be implicated as causes. The data suggest that many who did not respond were carriers raise possibility it is more difficult carrier than acutely infected individual.
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