fPoxDB: fungal peroxidase database for comparative genomics

摘要: Background: Peroxidases are a group of oxidoreductases which mediate electron transfer from hydrogen peroxide (H2O2) and organic to various acceptors. They possess broad spectrum impact on industry fungal biology. There numerous industrial applications using peroxidases, such as catalyse highly reactive pollutants breakdown lignin for recycling carbon sources. Moreover, genes encoding peroxidases play important roles in pathogenicity both humans plants. For better understanding at the genome-level, novel genomics platform is required. To this end, Fungal Peroxidase Database (fPoxDB; http://peroxidase.riceblast.snu.ac.kr/) has been developed provide gene family. Description: In order identify classify 24 sequence profiles were built applied 331 genomes including 216 fungi Oomycetes. addition, NoxR, known regulate NADPH oxidases (NoxA NoxB) fungi, was also added pipeline. Collectively, 6,113 predicted encode 25 families, presenting well-separated distribution along taxonomy. instance, peroxidase, manganese versatile peroxidase concentrated rot-causing basidiomycetes, reflecting their ligninolytic capability. As platform, fPoxDB provides diverse analysis resources, family predictions based profiles, pre-computed results eight bioinformatics programs, similarity search tools, multiple alignment tool, domain functions, taxonomic summary, some not available previously resource. interconnected with other web systems, providing extended opportunities. Conclusions: fungi-oriented peroxidases. The sequence-based prediction toolkits easy-to-follow interface offer useful workbench study comparative evolutionary fungi.