Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals
作者： Clemens Schroeder , Min Tae M. Park , Jürgen Germann , M. Mallar Chakravarty , Lars Michels
DOI: 10.1111/EJN.13408
关键词:
摘要: Aβ deposition is a driving force of Alzheimer's disease pathology and can be detected early by amyloid positron emission tomography. Identifying presymptomatic structural brain changes associated with might lead to better understanding its consequences provide diagnostic information. In this respect we analyzed measures cortical thickness subcortical volumes along hippocampal, thalamic striatal shape surface area applying novel analysis strategies for magnetic resonance imaging. We included 69 cognitively normal elderly subjects after careful clinical neuropsychological workup. Standardized uptake value ratios (cerebellar reference) 11-C-Pittsburgh Compound B (PiB) were calculated from tomographic data measurement bilateral hippocampus, thalamus striatum. Associations shape, area, volume tested using regression models that significant predictors as covariates. Left anterior hippocampal was regional PiB (P 0.05, FDR corrected). Within the entorhinal region both hemispheres, negatively (P < 0.05, Hence, localized may potential biomarkers disease.
uzh.ch
sci-hub.se 参考文章(64)
John C. Mazziotta, Arthur W. Toga, Alan Evans, Peter Fox, Jack Lancaster, A Probabilistic Atlas of the Human Brain: Theory and Rationale for Its Development: The International Consortium for Brain Mapping (ICBM) NeuroImage. ,vol. 2, pp. 89- 101 ,(1995) , 10.1006/NIMG.1995.1012
Reisa A. Sperling, Paul S. Aisen, Laurel A. Beckett, David A. Bennett, Suzanne Craft, Anne M. Fagan, Takeshi Iwatsubo, Clifford R. Jack, Jeffrey Kaye, Thomas J. Montine, Denise C. Park, Eric M. Reiman, Christopher C. Rowe, Eric Siemers, Yaakov Stern, Kristine Yaffe, Maria C. Carrillo, Bill Thies, Marcelle Morrison-Bogorad, Molly V. Wagster, Creighton H. Phelps, Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease Alzheimers & Dementia. ,vol. 7, pp. 280- 292 ,(2011) , 10.1016/J.JALZ.2011.03.003
Alexander Hammers, Richard Allom, Matthias J. Koepp, Samantha L. Free, Ralph Myers, Louis Lemieux, Tejal N. Mitchell, David J. Brooks, John S. Duncan, Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe Human Brain Mapping. ,vol. 19, pp. 224- 247 ,(2003) , 10.1002/HBM.10123
June Sic Kim, Vivek Singh, Jun Ki Lee, Jason Lerch, Yasser Ad-Dab'bagh, David MacDonald, Jong Min Lee, Sun I Kim, Alan C Evans, None, Automated 3-D extraction and evaluation of the inner and outer cortical surfaces using a Laplacian map and partial volume effect classification NeuroImage. ,vol. 27, pp. 210- 221 ,(2005) , 10.1016/J.NEUROIMAGE.2005.03.036
Victor L Villemagne, Samantha Burnham, Pierrick Bourgeat, Belinda Brown, Kathryn A Ellis, Olivier Salvado, Cassandra Szoeke, S Lance Macaulay, Ralph Martins, Paul Maruff, David Ames, Christopher C Rowe, Colin L Masters, Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study The Lancet Neurology. ,vol. 12, pp. 357- 367 ,(2013) , 10.1016/S1474-4422(13)70044-9
Jason P. Lerch, Jeffrey B. Carroll, Shoshana Spring, Lisa N. Bertram, Claudia Schwab, Michael R. Hayden, R. Mark Henkelman, Automated deformation analysis in the YAC128 Huntington disease mouse model. NeuroImage. ,vol. 39, pp. 32- 39 ,(2008) , 10.1016/J.NEUROIMAGE.2007.08.033
D. Louis Collins, Peter Neelin, Terrence M. Peters, Alan C. Evans, Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space Journal of Computer Assisted Tomography. ,vol. 18, pp. 192- 205 ,(1994) , 10.1097/00004728-199403000-00005
Moo K. Chung, J. Taylor, Diffusion smoothing on brain surface via finite element method 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano (IEEE Cat No. 04EX821). pp. 432- 435 ,(2004) , 10.1109/ISBI.2004.1398567
Jussi Tohka, Alex Zijdenbos, Alan Evans, Fast and robust parameter estimation for statistical partial volume models in brain MRI. NeuroImage. ,vol. 23, pp. 84- 97 ,(2004) , 10.1016/J.NEUROIMAGE.2004.05.007
Paul M. Thompson, Kiralee M. Hayashi, Greig de Zubicaray, Andrew L. Janke, Stephen E. Rose, James Semple, David Herman, Michael S. Hong, Stephanie S. Dittmer, David M. Doddrell, Arthur W. Toga, Dynamics of Gray Matter Loss in Alzheimer's Disease The Journal of Neuroscience. ,vol. 23, pp. 994- 1005 ,(2003) , 10.1523/JNEUROSCI.23-03-00994.2003