The utility of PET-based imaging for prostate cancer biochemical recurrence: a systematic review and meta-analysis.

摘要: Conventional imaging modalities have been poor in characterizing the true extent of disease men with biochemical recurrence following primary treatment for prostate cancer. Functional positron emission tomography (PET) has shown promise being a superior modality. We conducted systematic review and meta-analysis to define diagnostic accuracy PET/CT using 11C-choline, 18F-FACBC, or 68Ga-PSMA detecting recurrent searched multiple databases line preferred reporting items (PRISMA) statement PET/CT. Only studies secondarily staging participants those an appropriate reference standard (pathology, further imaging, and/or clinical response) were eligible analysis. Twenty-one 3202 met inclusion criteria. Of these, tracer investigated 16, 5, 1 studies, respectively. The summary sensitivity each was 80.9% (95% CI 70.4–88.3%), 79.7% 51.9–93.4%), 76.4% 68.3–82.9%), corresponding specificity 84.1% 70.2–92.2%), 61.9% 41.1–79.0%), 99.8% 97.5–100%), Detection rates ranged between 58.6 82.8%. All included judged be at high risk bias primarily due study limitations pertaining standard. There is lack high-quality data verify PET-based 68Ga-PSMA. early results are encouraging that these techniques conventional modalities, which would allow salvage therapies optimized.