Evaluation of an Electro-Pneumatic Device for Artificial Capillary Pulse Generation used in a Prospective Study in Animals for Surgical Neck Wound Healing.

作者: J. Foltyn , A. Proto , D. Oczka , R. Halfar , T. Klinkovsky

DOI: 10.1038/S41598-019-46397-0

关键词:

摘要: The paper examines the development and testing of an electro-pneumatic device for wound healing therapy after surgery in neck area. generates air pressure values a miniaturized cuff using electronic circuitry to drive electro-valve compressor. works two distinct modes: continuous mode pulsating mode. value setting can vary from 3 11 mmHg, mode’s operating frequency range is approximately 0.1 0.3 Hz. Laboratory measurements were conducted evaluate device’s correct functioning both modes. A four-day prospective study with animals (n = 10) was also device. Out twelve histological parameters analysed reveal differences between experimental control wounds, only one demonstrated significant difference. ten treated device, three showed difference terms benefit therapy. We therefore conclude that potentially improves process area if pre-set does not exceed 8 mmHg.

参考文章(51)
A. C. Shore, D. D. Sandeman, J. E. Tooke, Capillary pressure, pulse pressure amplitude, and pressure waveform in healthy volunteers. American Journal of Physiology-heart and Circulatory Physiology. ,vol. 268, ,(1995) , 10.1152/AJPHEART.1995.268.1.H147
H. Partsch, P. Mortimer, Compression for leg wounds British Journal of Dermatology. ,vol. 173, pp. 359- 369 ,(2015) , 10.1111/BJD.13851
Angela C. Shore, Capillaroscopy and the measurement of capillary pressure British Journal of Clinical Pharmacology. ,vol. 50, pp. 501- 513 ,(2000) , 10.1046/J.1365-2125.2000.00278.X
Duncan Sharp, Printed composite electrodes for in-situ wound pH monitoring. Biosensors and Bioelectronics. ,vol. 50, pp. 399- 405 ,(2013) , 10.1016/J.BIOS.2013.06.042
C.A. Cuenod, D. Balvay, Perfusion and vascular permeability: basic concepts and measurement in DCE-CT and DCE-MRI. Diagnostic and interventional imaging. ,vol. 94, pp. 1187- 1204 ,(2013) , 10.1016/J.DIII.2013.10.010
Min Zhao, Bing Song, Jin Pu, Teiji Wada, Brian Reid, Guangping Tai, Fei Wang, Aihua Guo, Petr Walczysko, Yu Gu, Takehiko Sasaki, Akira Suzuki, John V. Forrester, Henry R. Bourne, Peter N. Devreotes, Colin D. McCaig, Josef M. Penninger, Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN Nature. ,vol. 442, pp. 457- 460 ,(2006) , 10.1038/NATURE04925
Dae-Hyeong Kim, Shuodao Wang, Hohyun Keum, Roozbeh Ghaffari, Yun-Soung Kim, Hu Tao, Bruce Panilaitis, Ming Li, Zhan Kang, Fiorenzo Omenetto, Yonggang Huang, John A. Rogers, Thin, Flexible Sensors and Actuators as ‘Instrumented’ Surgical Sutures for Targeted Wound Monitoring and Therapy Small. ,vol. 8, pp. 3263- 3268 ,(2012) , 10.1002/SMLL.201200933
Manuel Ochoa, Rahim Rahimi, Babak Ziaie, Flexible Sensors for Chronic Wound Management IEEE Reviews in Biomedical Engineering. ,vol. 7, pp. 73- 86 ,(2014) , 10.1109/RBME.2013.2295817
Tim R. Dargaville, Brooke L. Farrugia, James A. Broadbent, Stephanie Pace, Zee Upton, Nicolas H. Voelcker, Sensors and imaging for wound healing: a review. Biosensors and Bioelectronics. ,vol. 41, pp. 30- 42 ,(2013) , 10.1016/J.BIOS.2012.09.029