Hepatotoxicity mechanisms of isoniazid: A mini-review.
作者： Hozeifa M Hassan , Hong‐li Guo , Bashir A Yousef , Zhang Luyong , Jiang Zhenzhou
DOI: 10.1002/JAT.3175
关键词:
摘要: Isoniazid (INH) is an antituberculosis drug associated with idiosyncratic liver injury in susceptible patients. INH-induced hepatotoxicity remains a significant clinical problem, but the underlying mechanisms are still unclear, despite growing evidence that INH and/or its major metabolite, hydrazine, play important role hepatotoxicity.
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