The incidence of, and factors leading to, parvovirus B19-related hydrops fetalis following maternal infection; report of 10 cases and meta-analysis

摘要: Objectives to clarify the approximation of frequency B19-related nonimmune hydrops fetalis (NIHF), and know critical period during which maternal infection led NIHF. Methods we investigated characteristics 10 cases antenatal B19 diagnosed over past years in Miyagi prefecture, Japan, performed a meta-analysis these those previously reported literature. Results NIHF caused by intrauterine was between 11 23 weeks gestaton women Japan. The source mother's older child six out cases, children at kindergarten where mothers worked two cases. interval onset diagnosis ranged from 2 6 weeks. responsible for (15.2%) 66 actiology unknown this study, 57 (19.1%) 299 non-malformed or aetilogy-unknown Meta-analysis 165 infection, including described above, showed that there 10.2%, excess risk fetal death infected with pregnancy 12.4% first 20 pregnancy. Transplacental transmission confirmed 69 (24.1%) 286 mean gestational age 22.8 ± 5.1 6.2 3.7 Conclusions approximations will be useful counselling management pregnant women. correlated hepatic hematopoietic activity. These findings suggest parvovirus may have an affinity erythroid lineage cells stage hematopoiesis, strongly influence clinical features feto-maternal infection.