Antioxidants and fetal protection against ethanol teratogenicity. I. Review of the experimental data and implications to humans.

摘要: Ethanol is the most common human teratogen, and heavy drinking during pregnancy can result in serious adverse outcomes to fetus. The cellular mechanisms by which ethanol induces damage utero are not well understood, while induction of oxidative stress believed be one putative mechanism. Our objective review data antioxidant effects experimental models fetal alcohol syndrome. Prior description available data, we will briefly leading ethanol-induced stress. Ethanol-induced fetus could attenuated a variety antioxidants as was documented whole animal tissue culture studies. Experiments, retrieved from literature search, described criticized. Although still limited, application treatment strategy that includes justified since for pre-eclampsia demonstrated safe effective. evidence safety vitamins C E suggest use alcohol-consuming mothers should seriously considered reduce damage.