Cholesterol and Alzheimer’s Disease: Statins, Cholesterol Depletion in APP Processing and Aβ Generation

摘要: Molecular and more specifically subcellular analyses of the neurodegenerative mechanisms involved in Alzheimer’s disease (AD) had been considered most time an interplay proteins genes. However, some observations could not be explained this way. Recently, a number research groups found missing link ... lipids! Among variety lipids that investigated, investigations focused on cholesterol derivatives. A recent statistic for every primary article AD cholesterol/statins, approximately two reviews were published. This clearly reflects as much interest topic, it gives evidence field is still its juvenile phase aspects have yet to covered or clarified. To date there evidently no final answer whether approach will eventually provide therapeutic solution treat prevent AD. At end day such answers can only obtained from clinical studies with suitable design published their results, one them preliminary results only. review focuses what we know about cellular AD-lipid connection kinds problematic issues; theoretical practical, are at hand.