Physicochemical and Antioxidant Properties of Riboflavin in Dextran70/HSA Systems.

摘要: Physicochemical properties of Riboflavin (Vitamin B2) (RF), in Dextran 70 (Dx70) (a biological relevant glucidic type macromolecule) and Human Serum Albumin (HSA) carrier/transport protein) based system, have been studied by absorption, fluorescence, circular dichroism electrochemistry. No significant changes on the fluorescence RF Dx70/HSA systems with without influence temperature (30-60 °C range) were observed. intrinsic Tryptophan Dx70/RF/HSA evidenced. HSA secondary structure when binds systems, a renaturation effect Dx70, was found. In system major process which undergoes is proton transfer, Ered = -0.43 V. Using chemiluminescence method, an improvement antioxidant activity into also concentration important oxidative damages it reacts target molecules thus promotes their oxidation. The results relevance stress pharmaceutical formulations containing RF.