Voltammetric Determination of Metronidazole Using a Sensor Based on Electropolymerization of α‐Cyclodextrin over a Carbon Paste Electrode
作者： Arturo Hernández-Jiménez , Gabriela Roa-Morales , Horacio Reyes-Pérez , Patricia Balderas-Hernández , Carlos E. Barrera-Díaz
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摘要: An electrochemical sensor for metronidazole (MTZ) was built via the surface modification of a carbon paste electrode (CPE) by film obtained through electropolymerization α-cyclodextrin (CPEα-CD). The CPEα-CD characterized cyclic voltammetry (CV) and atomic force microscopy (AFM), both techniques demonstrated that polymer is coating surface. electroreduction behaviour MTZ in HClO4 media as supporting electrolyte studied differential-pulse voltammetric (DPV) technique. DPV process observed to be diffusion controlled irreversible. Under optimal conditions, peak current proportional concentration range 0.5 103.0 μM with detection limit 0.28±0.02 μM. method successfully applied quantify pharmaceutical formulations. In addition, this proposed exhibited good reproducibility, long-term stability fast response.
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