Identification of Adenosine-3′,5′-Monophosphate as the Bacterial Attractant for Myxamoebae of Dictyostelium discoideum

摘要: Adenosine-3′,5′-cyclic monophosphate was shown to be the compound found in Escherichia coli responsible for attraction of amoebae cellular slime mold Dictyostelium discoideum. A number other nucleotides were tested and following active: tubercidin-3′,5′-cyclic monophosphate, N6-2′-O-dibutyryl-adenosine-3′,5′-cyclic 5′-methylene adenosine-3′,5′-cyclic monophosphonate, guanosine-3′,5′-cyclic uridine-3′,5′-cyclic cytidine-3′,5′-cyclic inosine-3′,5′-cyclic thymidine-3′,5′-cyclic monophosphate. They less active than It is suggested that cyclic adenosine secreted by bacteria used as a means sensing orienting towards food.