Cardiopulmonary Effects Following Local Irradiation of the Heart in Adult Male Wistar/Neuherberg Rats

摘要: Exposure to radiation of cosmic origin, which also com- prises part the natural terrestrial backround environment, poses potential detrimental biological effects as well complicated monitoring challenges (Hall, 1978; Tobias, 1985). The cardiovascular system is especially interesting and challenging because it an organ critical radiobiological importance, previously regarded a relatively radioresistant (Stewart et al 1967; Fajardo Stewart, 1973), currently under investigation in several animal models (Gavin Gillette, 1982; Gillette al, 1985; Lauk Yeung Hopewell, Moreover, physiological adjustments attributable unique space environment weightlessness are either or exert major influences upon this system. Some observed extended missions following: decrease blood volume; redistribution extracellular fluid; and, cardiac output. implementation in-flight exercise programs has proven useful minimizing these (Guyton, 1976).