A Review of phosphodiesterase-inhibition and the potential role for phosphodiesterase 4-inhibitors in clinical dermatology
作者： Steven R Feldman , Farah Moustafa
DOI:
关键词:
摘要: … In this paper, we review the characteristics and effects of phosphodiesterase inhibitors. We also review data on the efficacy and safety of two phosphodiesterase 4 inhibitors - apremilast …
参考文章(37)
J. R. Kanter, S. Prabhakar, N. Salomonis, K. Vranizan, I. Dubchak, B. R. Conklin, P. A. Insel, A. C. Zambon, L. Zhang, S. Minovitsky, Gene expression patterns define key transcriptional events in cell-cycle regulation by cAMP and protein kinase A Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 8561- 8566 ,(2005) , 10.1073/PNAS.0503363102
K Asadullah, W Sterry, K Stephanek, D Jasulaitis, M Leupold, H Audring, H D Volk, W D Döcke, IL-10 is a key cytokine in psoriasis. Proof of principle by IL-10 therapy: a new therapeutic approach. Journal of Clinical Investigation. ,vol. 101, pp. 783- 794 ,(1998) , 10.1172/JCI1476
Tsutomu Akama, Stephen J. Baker, Yong-Kang Zhang, Vincent Hernandez, Huchen Zhou, Virginia Sanders, Yvonne Freund, Richard Kimura, Kirk R. Maples, Jacob J. Plattner, Discovery and structure–activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis Bioorganic & Medicinal Chemistry Letters. ,vol. 19, pp. 2129- 2132 ,(2009) , 10.1016/J.BMCL.2009.03.007
Stephen I. Rennard, Neil Schachter, Mary Strek, Kathy Rickard, Ohad Amit, Cilomilast for COPD: Results of a 6-Month, Placebo-Controlled Study of a Potent, Selective Inhibitor of Phosphodiesterase 4 Chest. ,vol. 129, pp. 56- 66 ,(2006) , 10.1378/CHEST.129.1.56
Hermann Tenor, Erik Hedbom, Hans-Jörg Häuselmann, Christian Schudt, Armin Hatzelmann, Phosphodiesterase isoenzyme families in human osteoarthritis chondrocytes - functional importance of phosphodiesterase 4 British Journal of Pharmacology. ,vol. 135, pp. 609- 618 ,(2002) , 10.1038/SJ.BJP.0704480
Jessica Deree, Joilson O. Martins, Heidi Melbostad, William H. Loomis, Raul Coimbra, Insights into the regulation of TNF-a production in human mononuclear cells: the effects of non-specific phosphodiesterase inhibition Clinics. ,vol. 63, pp. 321- 328 ,(2008) , 10.1590/S1807-59322008000300006
Rachael Barber, George S. Baillie, Reinhard Bergmann, Malcolm C. Shepherd, Ruth Sepper, Miles D. Houslay, Gino Van Heeke, Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers American Journal of Physiology-lung Cellular and Molecular Physiology. ,vol. 287, ,(2004) , 10.1152/AJPLUNG.00384.2003
Ichiro Nomura, Elena Goleva, Michael D. Howell, Quatyba A. Hamid, Peck Y. Ong, Clifton F. Hall, Marc A. Darst, Bifeng Gao, Mark Boguniewicz, Jeffrey B. Travers, Donald Y. M. Leung, Cytokine Milieu of Atopic Dermatitis, as Compared to Psoriasis, Skin Prevents Induction of Innate Immune Response Genes Journal of Immunology. ,vol. 171, pp. 3262- 3269 ,(2003) , 10.4049/JIMMUNOL.171.6.3262
Vibeke Strand, David Fiorentino, ChiaChi Hu, Robert M Day, Randall M Stevens, Kim A Papp, Improvements in patient-reported outcomes with apremilast, an oral phosphodiesterase 4 inhibitor, in the treatment of moderate to severe psoriasis: results from a phase IIb randomized, controlled study Health and Quality of Life Outcomes. ,vol. 11, pp. 82- 82 ,(2013) , 10.1186/1477-7525-11-82
Pooneh Salari, Mohammad Abdollahi, Phosphodiesterase inhibitors in inflammatory bowel disease Expert Opinion on Investigational Drugs. ,vol. 21, pp. 261- 264 ,(2012) , 10.1517/13543784.2012.658915