Waist belt and central obesity cause partial hiatus hernia and short-segment acid reflux in asymptomatic volunteers

作者: Lee YeongYeh Lee YeongYeh , AA Wirz , JGH Whiting , EV Robertson , D Smith

DOI: 10.1136/GUTJNL-2013-305803

关键词:

摘要: Objective There is a high incidence of inflammation and metaplasia at the gastro-oesophageal junction (GOJ) in asymptomatic volunteers. Additionally, majority patients with GOJ adenocarcinomas have no history reflux symptoms. We report effects waist belt increased circumference (WC) on physiology Design 12 subjects normal WC, matched for age gender were examined fasted following meal belts off. A magnet was clipped to squamo-columnar (SCJ). Combined assembly magnet-locator probe, 12-channel pH catheter 36-channel manometer passed. Results The WC each associated proximal displacement SCJ within diaphragmatic hiatus (relative upper border lower oesophageal sphincter (LOS), peak LOS pressure point inversion point, PIP (all p Conclusions Our findings indicate that volunteers, central obesity cause partial herniation short-segment acid reflux. This provides plausible explanation occurrence neoplasia without

参考文章(29)
EV Robertson, YY Lee, MH Derakhshan, AA Wirz, JR Whiting, JP Seenan, P Connolly, KE McColl, None, High-resolution esophageal manometry: addressing thermal drift of the manoscan system. Neurogastroenterology and Motility. ,vol. 24, pp. 61- ,(2012) , 10.1111/J.1365-2982.2011.01817.X
R. K. Mittal, M. Fisher, R. W. McCallum, D. F. Rochester, J. Dent, J. Sluss, Human lower esophageal sphincter pressure response to increased intra-abdominal pressure. American Journal of Physiology-gastrointestinal and Liver Physiology. ,vol. 258, ,(1990) , 10.1152/AJPGI.1990.258.4.G624
YY Lee, JGH Whiting, EV Robertson, MH Derakhshan, AA Wirz, D Smith, D Morrison, A Kelman, P Connolly, KEL McColl, None, Kinetics of transient hiatus hernia during transient lower esophageal sphincter relaxations and swallows in healthy subjects Neurogastroenterology and Motility. ,vol. 24, pp. 990- 999 ,(2012) , 10.1111/J.1365-2982.2012.01948.X
David J. Prezant, Thomas K. Aldrich, Jill P. Karpel, Robert I. Lynn, Adaptations in the Diaphragm's In Vivo Force-Length Relationship in Patients on Continuous Ambulatory Peritoneal Dialysis The American review of respiratory disease. ,vol. 141, pp. 1342- 1349 ,(1990) , 10.1164/AJRCCM/141.5_PT_1.1342
Peter J. Kahrilas, Scott Wu, Shezhang Lin, Philippe Pouderoux, Attenuation of esophageal shortening during peristalsis with hiatus hernia Gastroenterology. ,vol. 109, pp. 1818- 1825 ,(1995) , 10.1016/0016-5085(95)90748-3
C. Weber, C. S. Davis, V. Shankaran, P. M. Fisichella, Hiatal hernias: a review of the pathophysiologic theories and implication for research Surgical Endoscopy and Other Interventional Techniques. ,vol. 25, pp. 3149- 3153 ,(2011) , 10.1007/S00464-011-1725-Y
N.D. Freedman, M.H. Derakhshan, C.C. Abnet, A. Schatzkin, A.R. Hollenbeck, K.E.L. McColl, Male predominance of upper gastrointestinal adenocarcinoma cannot be explained by differences in tobacco smoking in men versus women. European Journal of Cancer. ,vol. 46, pp. 2473- 2478 ,(2010) , 10.1016/J.EJCA.2010.05.005
Carlo La Vecchia, Eva Negri, Pagona Lagiou, Dimitrios Trichopoulos, Oesophageal adenocarcinoma: A paradigm of mechanical carcinogenesis? International Journal of Cancer. ,vol. 102, pp. 269- 270 ,(2002) , 10.1002/IJC.10697
Wylie J. Dodds, Walter J. Hogan, William N. Miller, John J. Stef, Ronald C. Arndorfer, Sean B. Lydon, Effect of increased intraabdominal pressure on lower esophageal sphincter pressure. Digestive Diseases and Sciences. ,vol. 20, pp. 298- 308 ,(1975) , 10.1007/BF01237786
Elaine V Robertson, Mohammad H Derakhshan, Angela A Wirz, Yeong Yeh Lee, John Paul Seenan, Stuart A Ballantyne, Scott L Hanvey, Andrew W Kelman, James J Going, Kenneth EL McColl, None, Central Obesity in Asymptomatic Volunteers Is Associated With Increased Intrasphincteric Acid Reflux and Lengthening of the Cardiac Mucosa Gastroenterology. ,vol. 145, pp. 730- 739 ,(2013) , 10.1053/J.GASTRO.2013.06.038