Beneficial Effect of Amantadine on Postoperative Pain Reduction and Consumption of Morphine in Patients Subjected to Elective Spine Surgery
作者： Beata Bujak-Giżycka , Katarzyna Kącka , Maciej Suski , Rafał Olszanecki , Józef Madej
DOI: 10.1111/J.1526-4637.2011.01321.X
关键词:
摘要: Objective. To analyze the effect of coadministration morphine and amantadine on postoperative pain reduction consumption in patients after elective spine surgery. Methods. In double-blinded study, 60 (ASA physical status I-II) were randomized into two groups. Group A was given oral 50 or 100 mg 1 hour before surgery 8, 20, 32 hours operation. P received placebo at identical times. Pain assessed using numerical rating scale first administration 2, 3, 4, 6, 24, 48 The amounts consumed recorded up to surgery. Blood samples taken twice 2 plasma levels its main metabolites measured. Results. As compared with placebo, significantly reduced intra-operative Fentanyl use sensation pain. Up operation, cumulative 25% lower group. Moreover, intensity nausea vomiting tended be Starting from 12th surgery, level sedation who amantadine, as No significant differences ant observed between groups. Conclusions. Pre- fentanyl during well decreased young undergoing orthopedic
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