Influence of calcitonin gene-related peptide release on pH-induced mechanical depression in rat atria.
作者： A. Gómez Alvis , V. Milesi , A. Rebolledo , J. Raingo , A. O. Grassi de Gende
DOI: 10.1536/JHJ.42.507
关键词:
摘要: Rat atria is richly innervated by sensory nerve fibers that release CGRP when stimulated either capsaicin or acid pH. We studied the physiological relevance of pH-induced on changes in atrial contractility and relaxation produced lowering Isolated electrically paced at 2.77 Hz were exposed to a 10-minute period metabolic acidosis (pH=6.73±0.01, n=28) after: 1) induced 0.5 μM; 2) blockage with ruthenium red (RR) 5 3) no pretreatment; 4) receptor CGRP8-37 1 μM. Contractility significantly less depressed pH was prevented RR activation blocked CGRP8-37. The results suggest receptors may be physiologically involved contributing depression rat atria.
sci-hub.st 参考文章(34)
V. Milesi, A. Rebolledo, A. Grassi, E. Mandrile, P. Quiroga, A. Gomez Alvis, Chronotropic, inotropic and lusitropic effects of capsaicin on isolated rat atria. Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia. ,vol. 48, pp. 65- 72 ,(1998)
Hsi Chiao, Robert W. Caldwell, The role of substance P in myocardial dysfunction during ischemia and reperfusion Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 353, pp. 400- 407 ,(1996) , 10.1007/BF00261436
A. O. de Gende, D. P. Alzueta, H. E. Cingolani, Effect of isoproterenol on relation between maximal rate of contraction and maximal rate of relaxation. American Journal of Physiology-heart and Circulatory Physiology. ,vol. 233, pp. 404- 409 ,(1977) , 10.1152/AJPHEART.1977.233.3.H404
Harout Hass�ssian, Guy Drapeau, R�jean Couture, Spinal action of neurokinins producing cardiovascular responses in the conscious freely moving rat: evidence for a NK-1 receptor mechanism. Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 338, pp. 649- 654 ,(1988) , 10.1007/BF00165629
Melissa E. Martenson, Susan L. Ingram, Thomas K. Baumann, Potentiation of rabbit trigeminal responses to capsaicin in a low pH environment. Brain Research. ,vol. 651, pp. 143- 147 ,(1994) , 10.1016/0006-8993(94)90690-4
A Fabiato, F Fabiato, Effects of pH on the myofilaments and the sarcoplasmic reticulum of skinned cells from cardiace and skeletal muscles. The Journal of Physiology. ,vol. 276, pp. 233- 255 ,(1978) , 10.1113/JPHYSIOL.1978.SP012231
Yuan-Jian Li, Zhou-Sheng Xiao, Chang-Fu Peng, Han-Wu Deng, Calcitonin gene-related peptide-induced preconditioning protects against ischemia-reperfusion injury in isolated rat hearts European Journal of Pharmacology. ,vol. 311, pp. 163- 167 ,(1996) , 10.1016/0014-2999(96)00426-8
SILVIA SIGRIST, ANDERS FRANCO-CERECEDA, ROMAN MUFF, HERMANN HENKE, JAN M. LUNDBERG, JAN A. FISCHER, Specific Receptor and Cardiovascular Effects of Calcitonin Gene-Related Peptide Endocrinology. ,vol. 119, pp. 381- 389 ,(1986) , 10.1210/ENDO-119-1-381
Angela O. Grassi, Ramón A. Cirigliano, Horacio E. Cingolani, Myocardial Potassium Balance and Metabolic Acid-Base Alterations in the Perfused Rat Heart Archives Internationales de Physiologie et de Biochimie. ,vol. 81, pp. 427- 437 ,(1973) , 10.3109/13813457309073394
P. Ferdinandy, Tamás Csont, Csaba Csonka, Marianna Török, Mária Dux, József Németh, László I. Horváth, László Dux, Zoltán Szilvássy, Gábor Jancsó, Capsaicin-sensitive local sensory innervation is involved in pacing-induced preconditioning in rat hearts: role of nitric oxide and CGRP? Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 356, pp. 356- 363 ,(1997) , 10.1007/PL00005062