Treatment of Early Childhood Medulloblastoma by Postoperative Chemotherapy Alone

摘要: Background The prognosis for young children with medulloblastoma is poor, and survivors are at high risk cognitive deficits. We conducted a trial of the treatment this brain tumor by intensive postoperative chemotherapy alone. Methods After surgery, received three cycles intravenous (cyclophosphamide, vincristine, methotrexate, carboplatin, etoposide) intraventricular methotrexate. Treatment was terminated if complete remission achieved. Leukoencephalopathy deficits were evaluated. Results Forty-three treated according to protocol. In who had resection (17 patients), residual (14), macroscopic metastases (12), five-year progression-free overall survival rates (±SE) 82±9 percent 93±6 percent, 50±13 56±14 33±14 38±15 respectively. in 31 patients without 68±8 77±8 percent. Desmoplastic histology, ...