Cyclin-Dependent Kinase 11 (CDK11) Is Required for Ovarian Cancer Cell Growth In Vitro and In Vivo, and Its Inhibition Causes Apoptosis and Sensitizes Cells to Paclitaxel

摘要: Ovarian cancer is currently the most lethal gynecologic malignancy with limited treatment options. Improved targeted therapies are needed to combat ovarian cancer. Here, we report identification of cyclin-dependent kinase 11 (CDK11) as a mediator tumor cell growth and proliferation in cells. Although CDK11 has not been implicated previously this disease, have found that its expression upregulated human tissues associated malignant progression. Metastatic recurrent tumors significantly higher when compared matched, original primary tumors. RNAi-mediated silencing by synthetic siRNA or lentiviral shRNA decreased induced apoptosis Moreover, knockdown enhances cytotoxic effect paclitaxel inhibit Systemic vivo administration reduced an xenograft model. Our findings suggest may be promising therapeutic target for patients. Mol Cancer Ther; 15(7); 1691-701. ©2016 AACR.