Comparison of pediatric and adult medullary thyroid carcinoma based on SEER program.
作者： Zhuang Zhao , Xiang-dang Yin , Xu-he Zhang , Zhi-wen Li , Dun-wei Wang
DOI: 10.1038/S41598-020-70439-7
关键词:
摘要: To compare the clinicopathological characteristics and survival outcomes of children adult diagnosed with medullary thyroid carcinoma (MTC). MTC patients were extracted from Surveillance, Epidemiology End Results (SEER) database 1998 to 2016, followed by stratification into pediatric (< 20 years) or (≥ 20 years) groups. In total, 2,197 (110 2087 adult) identified. Pediatric more likely have localized stage (70.0% vs. 51.6%), negative regional nodes (48.2% 30.8%) receive total/subtotal thyroidectomy surgery (97.3% 85.3%). Moreover, CSS OS rates significantly higher in (both P < 0.001). Multivariable Cox regression analysis revealed that correlated worse [(CSS: HR 11.60, 95% CI 1.62–83.02, P = 0.015); (OS: 5.63, 2.08–15.25, P = 0.001)]. Further stratified indicated group might significant better for advanced stage. Patients earlier prognosis was than patients.
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