Tracing the network connecting BRCA and Fanconi anaemia proteins.
作者： Ashok R. Venkitaraman
DOI: 10.1038/NRC1321
关键词:
摘要: Recent evidence connects the proteins that are encoded by BRCA1 and BRCA2 breast cancer susceptibility genes, other tumour suppressors — such as Fanconi anaemia gene products to cell-cycle checkpoint control DNA repair homologous recombination. Do these connections represent a linear biological pathway or do they, instead, reflect network of processes prevent aberrations in chromosome structure during S G2 phases cell cycle? This distinction has important implications for current models explain pathogenesis syndromes associated with BRCA mutations.
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