A2780 human ovarian cancer cells with acquired paclitaxel resistance display cancer stem cell properties
作者： XIAOFENG HAN , FANGFANG DU , LI JIANG , YIFEI ZHU , ZHEN CHEN
DOI: 10.3892/OL.2013.1568
关键词:
摘要: The use of chemotherapy to treat cancer is effective, but chemoresistance reduces this efficacy. Chemotherapy resistance involves several mechanisms, including the stem cell (CSC) concept. aim present study was assess whether paclitaxel-resistant epithelial ovarian carcinoma capable generating cells with CSC-like properties. Using A2780/PTX line, it demonstrated that high aldehyde dehydrogenase 1 (ALDH1) activity identifies CSCs from diverse sources. Furthermore, had a strong ability form colonies in soft agar assays. Notably, inhibition PI3K signaling pathway abolished colony formation. These data suggest there link between paclitaxel and CSC enrichment. It possible therapeutic benefits, such as restoration chemosensitivity or suppression tumorigenicity, may be enabled by gaining further insights into mechanisms underlying generation CSCs.
sci-hub.se 参考文章(24)
Jianxing He, Wenju Lu, Qi Zhang, Haihong Yang, Regulation of calcium signaling in lung cancer Journal of Thoracic Disease. ,vol. 2, pp. 52- 56 ,(2010) , 10.3978/J.ISSN.2072-1439.2010.02.01.015
B Cvek, Comment on 'cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells'. British Journal of Cancer. ,vol. 108, pp. 993- 993 ,(2013) , 10.1038/BJC.2013.18
Giovanni D. Aletti, Mary M. Gallenberg, William A. Cliby, Aminah Jatoi, Lynn C. Hartmann, Current Management Strategies for Ovarian Cancer Mayo Clinic Proceedings. ,vol. 82, pp. 751- 770 ,(2007) , 10.4065/82.6.751
Michael F Clarke, John E Dick, Peter B Dirks, Connie J Eaves, Catriona HM Jamieson, D Leanne Jones, Jane Visvader, Irving L Weissman, Geoffrey M Wahl, None, Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Research. ,vol. 66, pp. 9339- 9344 ,(2006) , 10.1158/0008-5472.CAN-06-3126
Alex Chang, Chemotherapy, chemoresistance and the changing treatment landscape for NSCLC Lung Cancer. ,vol. 71, pp. 3- 10 ,(2011) , 10.1016/J.LUNGCAN.2010.08.022
Alysha K. Croker, David Goodale, Jenny Chu, Carl Postenka, Benjamin D. Hedley, David A. Hess, Alison L. Allan, High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability. Journal of Cellular and Molecular Medicine. ,vol. 13, pp. 2236- 2252 ,(2009) , 10.1111/J.1582-4934.2008.00455.X
P Liu, S Brown, T Goktug, P Channathodiyil, V Kannappan, J-P Hugnot, P-O Guichet, X Bian, A L Armesilla, J L Darling, W Wang, Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells. British Journal of Cancer. ,vol. 107, pp. 1488- 1497 ,(2012) , 10.1038/BJC.2012.442
Cristóbal Aguilar-Gallardo, Emily Cecilia Rutledge, Ana M. Martínez-Arroyo, Juan José Hidalgo, Santiago Domingo, Carlos Simón, Overcoming Challenges of Ovarian Cancer Stem Cells: Novel Therapeutic Approaches Stem Cell Reviews and Reports. ,vol. 8, pp. 994- 1010 ,(2012) , 10.1007/S12015-011-9344-5
Lijuan Wang, Roman Mezencev, Nathan J. Bowen, Lilya V. Matyunina, John F. McDonald, Isolation and characterization of stem-like cells from a human ovarian cancer cell line Molecular and Cellular Biochemistry. ,vol. 363, pp. 257- 268 ,(2012) , 10.1007/S11010-011-1178-6
Thomas Dittmar, Christoph Heyder, Eva Gloria-Maercker, Wolfgang Hatzmann, Kurt S. Zänker, Adhesion molecules and chemokines: the navigation system for circulating tumor (stem) cells to metastasize in an organ-specific manner. Clinical & Experimental Metastasis. ,vol. 25, pp. 11- 32 ,(2008) , 10.1007/S10585-007-9095-5