作者: Adriana F. Faria , Juliana P. Vasconcelos , Raoni S. B. Gonçalves , Marcus V. N. de Souza , Marcone A. L. de Oliveira
DOI: 10.1007/S10337-012-2308-3
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摘要: An alternative methodology for simultaneous determination of isoniazid, isonicotinic acid, 4-cyanopyridine, ethyl isonicotinate and isonicotinamide by capillary zone electrophoresis, within an analysis time 11 min, is proposed. electrolyte composed 50 mmol L−1 acetic acid/sodium acetate buffer 12.5 Cu2+, analyte dilution in 1 Brij 35 Cu2+ +20 kV voltage were optimized. After evaluating some figures merit, such as linearity, precision, recovery quantification limit, the method was successfully applied to isoniazid tablets. The contents found 99.3 mg 0.3 corresponding % impurity regarding content active ingredient pharmaceutical formulation.