THE ROLE OF SEROTONIN AND DOPAMINE IN HYPOTHALAMIC-PITUITARY FUNCTION

摘要: Neuroendocrinology has developed as a major discipline out of the important early concepts Harris (1948) and subsequent findings in 1960’s demonstrating that brain and, particular, hypothalamus, exerted an inhibitory influence on prolactin secretion (Pasteels, 1963; Talwalker et al., Danon e t 1963) stimulating growth hormone (GH) from pituitary gland (Roth Abrams 1964). That these hypothalamic influences were mediated by monoamine transmitters was suggested many groups (e.g. Kanematsu Ratner 1965; Muller 1967; Blackard & Heidingsfelder, 1968; Van Maanen Smelik, 1968) who used drugs such reserpine a-adrenergic blocking agents which interfere with activity monoamines. The individual roles specific monoamines function have been investigated diverse ways. use intraventricular injection amines dopamine, noradrenaline serotonin rat has, despite its limitations (Hokfelt Fuxe, 1972), laid much groundwork this area (Schneider McCann, 1970; Kamberi 1970, 1971; Marks Collu 1972). development fluorescence histochemistry (Corrodi Jonsson, Fuxe 1970) enabled localization cell bodies to be established, well aspects amine neuronal tuberoinfundibular dopaminergic (TIDA) neurons control prolactin-and gonadotrophin Another approach o problem establishing vivo for either precursors produce monoamines, or selectively (Donoso el 1971;Kleinberg Friesen 1972; Smythe Lazarus, 1973a, b; 1973; Bivens, Plonk, 1974; Smythe, 1975a, b, 1976; Liuzzi Chambers B Chihara 1976). These procedures established dopamine is involved some aspect secretory mechanisms each anterior hormones.