A tangled tale of molecular subtypes in pancreatic cancer
作者： Shiv Singh , Marie Christin Hasselluhn , Albrecht Neesse , None
DOI: 10.1136/GUTJNL-2018-318086
关键词:
摘要: Pancreatic ductal adenocarcinoma (PDAC) constitutes the most common malignancy of pancreas. With a 5-year survival rate below 10% and median less than 12 months following diagnosis, PDAC remains major biomedical challenge. Due to lack early symptoms patients are usually diagnosed with locally advanced or metastatic disease where surgical removal tumour is no longer feasible. Despite some recent developments in medical oncology, response chemotherapeutic regimens such as nab-paclitaxel FOLFIRINOX limited accompanied by side effects nausea, neutropenia, neuropathy infectious complications.1 Histologically, majority cases characterised tubular glands embedded pronounced microenvironment (TME) composed acellular components collagen, hyaluronic acid, fibronectin abundant matricellular proteins. Moreover, inflammatory cells tumour-associated macrophages, neutrophils, regulatory T cells, cancer-associated fibroblasts neural accumulate around neoplastic actively contribute TME formation tumour-stroma crosstalk.2 Notably, histopathological features have not yet been used to select therapeutic strategies. However, increasing evidence from other entities breast, melanoma, lung colon cancer suggest that molecular characteristics can vastly differ microscopically indistinguishable cancers. advent high-throughput sequencing technologies whole-genome profiling transcriptome profiling, taxonomy cancers has become …
sci-hub.se 参考文章(8)
Mark S Talamonti, Christine A Iacobuzio-Donahue, Michael A Hollingsworth, Jen Jen Yeh, Richard A Moffitt, Raoud Marayati, Elizabeth L Flate, Keith E Volmar, S Gabriela Herrera Loeza, Katherine A Hoadley, Naim U Rashid, Lindsay A Williams, Samuel C Eaton, Alexander H Chung, Jadwiga K Smyla, Judy M Anderson, Hong Jin Kim, David J Bentrem, Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma Nature Genetics. ,vol. 47, pp. 1168- 1178 ,(2015) , 10.1038/NG.3398
Eric A Collisson, Anguraj Sadanandam, Peter Olson, William J Gibb, Morgan Truitt, Shenda Gu, Janine Cooc, Jennifer Weinkle, Grace E Kim, Lakshmi Jakkula, Heidi S Feiler, Andrew H Ko, Adam B Olshen, Kathleen L Danenberg, Margaret A Tempero, Paul T Spellman, Douglas Hanahan, Joe W Gray, Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy. Nature Medicine. ,vol. 17, pp. 500- 503 ,(2011) , 10.1038/NM.2344
Peter Bailey, David K Chang, Katia Nones, Amber L Johns, Ann-Marie Patch, Marie-Claude Gingras, David K Miller, Angelika N Christ, Tim JC Bruxner, Michael C Quinn, Craig Nourse, L Charles Murtaugh, Ivon Harliwong, Senel Idrisoglu, Suzanne Manning, Ehsan Nourbakhsh, Shivangi Wani, Lynn Fink, Oliver Holmes, Venessa Chin, Matthew J Anderson, Stephen Kazakoff, Conrad Leonard, Felicity Newell, Nick Waddell, Scott Wood, Qinying Xu, Peter J Wilson, Nicole Cloonan, Karin S Kassahn, Darrin Taylor, Kelly Quek, Alan Robertson, Lorena Pantano, Laura Mincarelli, Luis N Sanchez, Lisa Evers, Jianmin Wu, Mark Pinese, Mark J Cowley, Marc D Jones, Emily K Colvin, Adnan M Nagrial, Emily S Humphrey, Lorraine A Chantrill, Amanda Mawson, Jeremy Humphris, Angela Chou, Marina Pajic, Christopher J Scarlett, Andreia V Pinho, Marc Giry-Laterriere, Ilse Rooman, Jaswinder S Samra, James G Kench, Jessica A Lovell, Neil D Merrett, Christopher W Toon, Krishna Epari, Nam Q Nguyen, Andrew Barbour, Nikolajs Zeps, Kim Moran-Jones, Nigel B Jamieson, Janet S Graham, Fraser Duthie, Karin Oien, Jane Hair, Robert Grützmann, Anirban Maitra, Christine A Iacobuzio-Donahue, Christopher L Wolfgang, Richard A Morgan, Rita T Lawlor, Vincenzo Corbo, Claudio Bassi, Borislav Rusev, Paola Capelli, Roberto Salvia, Giampaolo Tortora, Debabrata Mukhopadhyay, Gloria M Petersen, Australian Pancreatic Cancer Genome Initiative, Donna M Munzy, William E Fisher, Saadia A Karim, James R Eshleman, Ralph H Hruban, Christian Pilarsky, Jennifer P Morton, Owen J Sansom, Aldo Scarpa, Elizabeth A Musgrove, Ulla-Maja Hagbo Bailey, Oliver Hofmann, Robert L Sutherland, David A Wheeler, Anthony J Gill, Richard A Gibbs, John V Pearson, Nicola Waddell, Andrew V Biankin, Sean M Grimmond, None, Genomic analyses identify molecular subtypes of pancreatic cancer Nature. ,vol. 531, pp. 47- 52 ,(2016) , 10.1038/NATURE16965
Kyaw L. Aung, Sandra E. Fischer, Robert E. Denroche, Gun-Ho Jang, Anna Dodd, Sean Creighton, Bernadette Southwood, Sheng-Ben Liang, Dianne Chadwick, Amy Zhang, Grainne M. O'Kane, Hamzeh Albaba, Shari Moura, Robert C. Grant, Jessica K. Miller, Faridah Mbabaali, Danielle Pasternack, Ilinca M. Lungu, John M.S. Bartlett, Sangeet Ghai, Mathieu Lemire, Spring Holter, Ashton A. Connor, Richard A. Moffitt, Jen Jen Yeh, Lee Timms, Paul M. Krzyzanowski, Neesha Dhani, David Hedley, Faiyaz Notta, Julie M. Wilson, Malcolm J. Moore, Steven Gallinger, Jennifer J. Knox, Genomics-Driven Precision Medicine for Advanced Pancreatic Cancer: Early Results from the COMPASS Trial Clinical Cancer Research. ,vol. 24, pp. 1344- 1354 ,(2017) , 10.1158/1078-0432.CCR-17-2994
John P. Neoptolemos, Jörg Kleeff, Patrick Michl, Eithne Costello, William Greenhalf, Daniel H. Palmer, Therapeutic developments in pancreatic cancer: current and future perspectives. Nature Reviews Gastroenterology & Hepatology. ,vol. 15, pp. 333- 348 ,(2018) , 10.1038/S41575-018-0005-X
Albrecht Neesse, Christian Alexander Bauer, Daniel Öhlund, Matthias Lauth, Malte Buchholz, Patrick Michl, David A Tuveson, Thomas M Gress, Stromal biology and therapy in pancreatic cancer : ready for clinical translation? Gut. ,vol. 68, pp. 159- 171 ,(2019) , 10.1136/GUTJNL-2018-316451
Francesco Puleo, Rémy Nicolle, Yuna Blum, Jérôme Cros, Laetitia Marisa, Pieter Demetter, Eric Quertinmont, Magali Svrcek, Nabila Elarouci, Juan Iovanna, Denis Franchimont, Laurine Verset, Maria Gomez Galdon, Jacques Devière, Aurelien De Reynies, Pierre Laurent-Puig, Jean-Luc Van Laethem, Jean-Baptiste Bachet, Raphael Marechal, None, Stratification of Pancreatic Ductal Adenocarcinomas Based on Tumor and Microenvironment Features. Gastroenterology. ,vol. 155, pp. 1999- ,(2018) , 10.1053/J.GASTRO.2018.08.033
Carlo Maurer, Sam R Holmstrom, Jing He, Pasquale Laise, Tao Su, Aqeel Ahmed, Hanina Hibshoosh, John A Chabot, Paul E Oberstein, Antonia R Sepulveda, Jeanine M Genkinger, Jiapeng Zhang, Alina C Iuga, Mukesh Bansal, Andrea Califano, Kenneth P Olive, None, Experimental microdissection enables functional harmonisation of pancreatic cancer subtypes Gut. ,vol. 68, pp. 1034- 1043 ,(2019) , 10.1136/GUTJNL-2018-317706