Blood lead and cadmium levels in occupationally exposed workers and their effect on markers of DNA damage and repair.
作者： Preeti Singh , Prasenjit Mitra , Taru Goyal , Shailja Sharma , Praveen Sharma
DOI: 10.1007/S10653-020-00696-Y
关键词:
摘要: Occupational exposure to heavy metals like lead and cadmium causes a wide range of biological effects may elevate the risk genetic damage. Heavy metal toxicity is now becoming significant public health problem. There are many discrepancies in results studies on genotoxicity metals. Therefore, study aimed estimate lead, cadmium, 8-OHdG levels (8-hydroxy-2-deoxyguanosine) expression DNA repair gene OGG1 (8-oxoguanine glycosylase 1) occupationally exposed workers. The comprised 100 workers, from different factories controls without history exposure. mean ± SD were 5.69 ± 12.07 µg/dL 3.44 ± 1.33 µg/L cases 1.27 ± 1.10 µg/dL 1.07 ± 0.67 µg/L controls. concentration was significantly higher than Cadmium showed positive correlation with cases. down-regulated compared Lead did not show any OGG1, whereas level had To conclude, associated increased oxidative damage impaired gene, OGG1.
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