Meningeal carcinomatosis in small cell carcinoma of the lung.

摘要: Abstract Cerebral and meningeal metastases are increasingly important complications in small cell anaplastic carcinoma of the lung. In a study at this institution, 60 evaluable patients received intensive chemotherapy without prophylactic cranial irradiation or other measures. The complete plus partial remission rate was 78 percent with median survival 49+ weeks (range eight to 106+ weeks) for those response 18+ six 67 response, all which comparable reported series. 11 (18 percent) carcinomatosis has developed. Forty-two relapse have exhibited 27 it only site relapse. occurred who had relapse, 12 sole Simultaneous cerebral 8 time compared 25+ (six over-all, 28 14 82 (two whole group Meningeal involvement lung must now be considered sanctuary equal importance metastases. To prevent treat complication will necessitate evaluation available modalities, including spinal irradiation, intrathecal systemic agents that readily cross blood-brain barrier.