Increased astrocyte expression of IL-6 or CCL2 in transgenic mice alters levels of hippocampal and cerebellar proteins.

摘要: ABSTRACT Emerging research has identified that neuroimmune factors are produced by cells of the central nervous system (CNS) and play critical roles as regulators CNS function, directors neurodevelopment responders to pathological processes. A wide range cells, primarily glial but role specific their cell sources in biology pathology have yet be fully elucidated. We used transgenic mice express elevated levels a factor, cytokine IL-6 or chemokine CCL2, through genetic modification astrocyte expression identify targets CCL2 at protein level. found non-transgenic constitutive occurs two regions studied, hippocampus cerebellum, measured ELISA. In were evident whereas mice, only cerebellum. Western blot analysis cellular synaptic proteins cerebellum showed resulted alterations these actions differed for brain regions. These results consistent with profiles action may an important aspect respective physiology pathophysiology.