Expression of Rb2/p130 in breast and endometrial cancer: correlations with hormone receptor status
作者： K Milde-Langosch , C Goemann , C Methner , G Rieck , A-M Bamberger
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摘要: Rb2/p130 is a member of the retinoblastoma family proteins, consisting Rb, Rb2 and p107, which are important negative regulators cell cycle progression differentiation. While downregulation was observed in several malignant tumours including endometrial cancer, role p130 breast carcinomas still unknown. We investigated protein expression tumour tissue from 68 mammary 41 carcinomas, 4 lines, normal samples. Therefore, we performed Western blot experiments for Rb2, oestrogen progesterone receptors (ER, PR-A, PR-B). Weak or absent more often found (59%) than (24%). significant positive correlations with ER, PR-B cancer samples, PR-B, younger age carcinomas. No associations histological grading, stage, nodal involvement, Ki67 staining were detected. mRNA studied by semi-quantitative RT-PCR 56 samples correlated significantly results. Our results indicate that loss expression, mostly transcriptional down-regulation, may be associated development dedifferentiation most subset © 2001 Cancer Research Campaign http://bjcancer.com
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A Baldi, Vincenzo Esposito, Antonio De Luca, Yan Fu, Ilernando Meoli, Giovan Giacomo Giordano, M Caputi, F Baldi, Antonio Giordano, None, Differential expression of Rb2/p130 and p107 in normal human tissues and in primary lung cancer. Clinical Cancer Research. ,vol. 3, pp. 1691- 1697 ,(1997)
F Baldi, A Baldi, C M Howard, M Caputi, A Giordano, A De Luca, V Esposito, G Mazzarella, Differential expression of the retinoblastoma gene family members pRb/p105, p107, and pRb2/p130 in lung cancer. Clinical Cancer Research. ,vol. 2, pp. 1239- 1245 ,(1996)
Bruno Calabretta, A Baldi, G Condorelli, N Colburn, Y Sun, A. Giordano, Y Fu, A De Luca, Pp Claudio, Cm Howard, p130/pRb2 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107. Cancer Research. ,vol. 54, pp. 5556- 5560 ,(1994)
N Tanaka, T Odajima, T Nakano, Y Kimijima, S Yamada, K Ogi, G Kohama, Immunohistochemical investigation of new suppressor oncogene p130 in oral squamous cell carcinoma Oral Oncology. ,vol. 35, pp. 321- 325 ,(1999) , 10.1016/S1368-8375(98)00089-X
Robert A Weinberg, The retinoblastoma protein and cell cycle control Cell. ,vol. 81, pp. 323- 330 ,(1995) , 10.1016/0092-8674(95)90385-2
Hung-Cheng Lai, Chien-An Sun, Mu-Hsien Yu, Huey-Jung Chen, Hang-Seng Liu, Tang-Yuan Chu, Favorable clinical outcome of cervical cancers infected with human papilloma virus type 58 and related types. International Journal of Cancer. ,vol. 84, pp. 553- 557 ,(1999) , 10.1002/(SICI)1097-0215(19991222)84:6<553::AID-IJC2>3.0.CO;2-4
Ana-Maria Bamberger, Carola Methner, Björn W. Lisboa, Carsten Städtler, Heinrich M. Schulte, Thomas Löning, Karin Milde-Langosch, Expression pattern of the AP-1 family in breast cancer: association of fosB expression with a well-differentiated, receptor-positive tumor phenotype. International Journal of Cancer. ,vol. 84, pp. 533- 538 ,(1999) , 10.1002/(SICI)1097-0215(19991022)84:5<533::AID-IJC16>3.0.CO;2-J
Shuan-fang Li, Tanri Shiozawa, Kuniaki Nakayama, Toshio Nikaido, Shingo Fujii, Stepwise abnormality of sex steroid hormone receptors, tumor suppressor gene products (p53 and Rb), and cyclin E in uterine endometrioid carcinoma. Cancer. ,vol. 77, pp. 321- 329 ,(1996) , 10.1002/(SICI)1097-0142(19960115)77:2<321::AID-CNCR15>3.0.CO;2-3
Junko Nishitani, Toru Nishinaka, Chi-Hong Cheng, Walter Rong, Kazunari K. Yokoyama, Robert Chiu, Recruitment of the retinoblastoma protein to c-Jun enhances transcription activity mediated through the AP-1 binding site. Journal of Biological Chemistry. ,vol. 274, pp. 5454- 5461 ,(1999) , 10.1074/JBC.274.9.5454
THILO SCHLOTT, SILKE REIMER, ANKE JAHNS, ANDREAS OHLENBUSCH, ILKA RUSCHENBURG, HOLGER NAGEL, MANFRED DROESE, Point mutations and nucleotide insertions in the MDM2 zinc finger structure of human tumours The Journal of Pathology. ,vol. 182, pp. 54- 61 ,(1997) , 10.1002/(SICI)1096-9896(199705)182:1<54::AID-PATH815>3.0.CO;2-I