The Effects of Flaxseed Dietary Supplement on Lipid Profile, Bone Mineral Density, and Symptoms in Menopausal Women: A Randomized, Double-Blind, Wheat Germ Placebo-Controlled Clinical Trial

摘要: Phytoestrogens are increasingly incorporated into the diet of menopausal women. However, there limited data on efficacy flaxseed consequences estrogen deficiency in The purpose study was to assess effects incorporation healthy One hundred and ninety-nine women were randomly assigned consume 40 g flaxseed/d (n = 101) or wheat germ placebo 98) for 12 months. At baseline at month 12, serum levels lipids, bone mineral density (BMD), symptoms evaluated. Statistical analysis performed under intention treat principle. Flaxseed reduced total (−0.20 ± 0.51 mmol/liter; P 0.012) high-density lipoprotein (−0.08 0.24 0.031) cholesterol concentrations compared with placebo. BMD did not differ significantly between two arms. Both (P < 0.0001) severity scores symptoms, but no ...