Preoperative flap-site injection with ropivacaine and epinephrine in BABA robotic and endoscopic thyroidectomy safely reduces postoperative pain

摘要: BACKGROUND Clinical trials on bilateral axillo-breast approach (BABA) thyroidectomy show that levobupivacaine and ropivacaine significantly reduce postoperative pain, but they focused BABA robotic only did not identify specific sites of significant pain relief. Our objective was to assess the reduction at various safety ropivacaine-epinephrine flap injection in thyroidectomy. METHODS This prospective double-blinded randomized controlled trial conducted compliance with revised CONSORT statement (ClinicalTrials.gov registration no. NCT02112370). Patients were into arm or control (normal saline) arm. RESULTS From January 2014 May 2016, 148 patients participated. The primary endpoint site-specific as measured by numeric rating scale 12 hours after surgery. group exhibited less swallowing difficulty (P = .008), anterior neck (P = .016), right (P = .019) left (P = .035) chest pain. Secondary endpoints systolic (P = .402), diastolic (P = .827) blood pressure, pulse rate (P = .397) before incision during vital signs groups just differ. During surgery, had higher rates (99 ± 13.3 vs 88 ± 16.1, P < .001) within normal range. There no adverse events such nausea vomiting. difference scores either patient between who underwent endoscopic interventions. CONCLUSION flap-site epinephrine mix effectively safely reduced Future studies should focus tailoring dosage for individuals.