Variability of gray and white matter during normal development: a voxel-based MRI analysis.

摘要: This study was aimed at investigating regional and local variability of brain tissue during normal human development. We investigated high-resolution MR-imaging data using SPM99 (Wellcome Department, University College London, UK). A pixel-wise variation coefficient gray white matter calculated to visualize variability. Data from 200 children (5–18 years) analyzed. We found a profound interaction between structures development in both matter. Variability shows regionally specific, age-related variations, possibly offering new tool for the assessment subtle abnormalities. Our results emphasize necessity take this into account when planning pediatric neuroimaging studies.