Combining cytotoxics and 17-allylamino, 17-demethoxygeldanamycin: sequence and tumor biology matters. Commentary re: P. Münster et al., Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner. Clin. Cancer Res., 7: 2228-2236, 2001
作者： Edward A. Sausville
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摘要: A surprising outcome of the search for agents that might target signaling systems drive cancer cell growth has been empirical observation many these drugs appear to potentiate effect conventional therapeutic agents. For example, herceptin, in both preclinical [(1)][1] and
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