Slow Blood-Brain Barrier Leakage Is Associated with Acute Brain Ischemia and Portends Increased Risk for Delayed Stroke (S47.007)

摘要: Objective: To assess blood-brain barrier dysfunction (BBBD) mapping in patients with transient neurological deficit, as a diagnostic and predictive biomarker required for risk stratification stroke prevention. Background: The diagnosis of ischemic attack (TIA) is challenging. Evidence acute ischemia on diffusion-weighted imaging (DWI) highly variable confirmed only about one-third patients. BBBD prominent feature cerebral key mechanism underlying delayed complications. Yet, to date, no clinical studies have characterized TIA. Design/Methods: Observational, single-center prospective cohort study conducted tertiary referral center from October 2012 through December 2016. We used dynamic contrast-enhanced MRI quantification fast slow 57 TIA/minor 50 healthy controls. Patients were followed until 31, 2017. Results: Mean age (64.9% men) was 58.4 years. Thirty-one (54.4%) had negative 26 (45.6%) positive DWI. extent significantly higher compared controls (65.3% men; mean age, 40.7 years; BBBD, P Conclusions: propose quantitative approach detection microvascular pathology subtle brain ischemia. Slow potential the development stroke. Disclosure: Dr. Serlin has nothing disclose. Ofer Ben-Arie Veksler Ifergane Shelef Minuk Horev Friedman