Catalytic Asymmetric (4+3) Cyclizations of In Situ Generated ortho-Quinone Methides with 2-Indolylmethanols.
作者： Meng Sun , Chun Ma , Si‐Jia Zhou , Sai‐Fan Lou , Jian Xiao
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摘要: Abstract The first catalytic asymmetric (4+ 3) cyclization of in situ generated ortho‐quinone methides with 2‐indolylmethanols has been established, which constructed seven‐membered heterocycles in high yields (up to 95%) and excellent enantioselectivity (up to 98%). This approach not only represents the first catalytic asymmetric (4+ 3) cyclization of o‐hydroxybenzyl alcohols, but also enabled an unprecedented catalytic asymmetric (4+ 3) cyclization of 2‐indolylmethanols. In addition, a scarcely reported catalytic asymmetric (4+ 3) …
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