Noncoding RNAs: Potential players in the self-renewal of mammalian spermatogonial stem cells.

摘要: Spermatogonial stem cells (SSCs), a unique population of male germ with self-renewal ability, are the foundation for maintenance spermatogenesis throughout life male. Although many regulatory molecules essential SSC have been identified, fundamental mechanism underlying how SSCs acquire and maintain their activity remains largely to be elucidated. In recent years, types noncoding RNAs (ncRNAs) suggested regulate through multiple ways, indicating ncRNAs play crucial roles in self-renewal. this paper, we mainly focus on four including microRNA, long ncRNA, piwi-interacting RNA, as well circular RNAs, reviewed potential that discovered recently help us gain better understanding molecular mechanisms by which perform function regulating