Gene Expression Profiling and its Practice in Drug Development
作者： Murty V. Chengalvala , Vargheese M. Chennathukuzhi , Daniel S. Johnston , Panayiotis E. Stevis , Gregory S. Kopf
DOI: 10.2174/138920207781386942
关键词:
摘要: The availability of sequenced genomes human and many experimental animals necessitated the development new technologies powerful computational tools that are capable exploiting these genomic data ask intriguing questions about complex nature biological processes. This gave impetus for developing whole genome approaches can produce functional information genes in form expression profiles unscramble relationships between variation gene resulting physiological outcome. These represent genetic fingerprints or cata- logue characterize cell tissue being studied provide a basis from which to begin an investigation underlying biology. Among most versatile high-density DNA microarrays analyze patterns large numbers across different tissues within same under variety experi- mental conditions even species. wide spread use microarray is generating sets stimulating better analytical so functions be predicted novel genes. In this review, authors discuss how used at various stages drug discovery process help identification targets, predict function genes, understand individual variability re- sponse drugs
eurekaselect.com参考文章(56)
Jim Oeppen, James W Vaupel, Broken Limits to Life Expectancy Science. ,vol. 296, pp. 1029- 1031 ,(2002) , 10.1126/SCIENCE.1069675
Paul Janssen, Benjamin Audit, Ildefonso Cases, Nikos Darzentas, Leon Goldovsky, Victor Kunin, Nuria Lopez-Bigas, José Peregrin-Alvarez, José B Pereira-Leal, Sophia Tsoka, Christos A Ouzounis, Beyond 100 genomes. Genome Biology. ,vol. 4, pp. 402- 402 ,(2003) , 10.1186/GB-2003-4-5-402
Françoise de Longueville, Dominic Surry, Georgina Meneses-Lorente, Vincent Bertholet, Valérie Talbot, Stephanie Evrard, Nathalie Chandelier, Andrew Pike, Phil Worboys, Jean-Paul Rasson, Béatrice Le Bourdellès, José Remacle, Gene expression profiling of drug metabolism and toxicology markers using a low-density DNA microarray Biochemical Pharmacology. ,vol. 64, pp. 137- 149 ,(2002) , 10.1016/S0006-2952(02)01055-9
Jason Lazarou, Bruce H. Pomeranz, Paul N. Corey, Incidence of Adverse Drug Reactions in Hospitalized Patients: A Meta-analysis of Prospective Studies JAMA. ,vol. 279, pp. 1200- 1205 ,(1998) , 10.1001/JAMA.279.15.1200
J.Craig Nelson, A review of the efficacy of serotonergic and noradrenergic reuptake inhibitors for treatment of major depression Biological Psychiatry. ,vol. 46, pp. 1301- 1308 ,(1999) , 10.1016/S0006-3223(99)00173-0
Tanja Heller, Julia Kirchheiner, Victor W Armstrong, Hilmar Luthe, Mladen Tzvetkov, J??rgen Brockm??ller, Michael Oellerich, AmpliChip CYP450 GeneChip: a new gene chip that allows rapid and accurate CYP2D6 genotyping. Therapeutic Drug Monitoring. ,vol. 28, pp. 673- 677 ,(2006) , 10.1097/01.FTD.0000246764.67129.2A
Tin Oo Khor, Sherif Ibrahim, Ah-Ng Tony Kong, Toxicogenomics in Drug Discovery and Drug Development: Potential Applications and Future Challenges Pharmaceutical Research. ,vol. 23, pp. 1659- 1664 ,(2006) , 10.1007/S11095-006-9003-8
E. C. Gunther, D. J. Stone, R. W. Gerwien, P. Bento, M. P. Heyes, Prediction of clinical drug efficacy by classification of drug-induced genomic expression profiles in vitro Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 9608- 9613 ,(2003) , 10.1073/PNAS.1632587100
Daniel S. Johnston, Scott A. Jelinsky, Hyun J. Bang, Paul DiCandeloro, Ewa Wilson, Gregory S. Kopf, Terry T. Turner, The Mouse Epididymal Transcriptome: Transcriptional Profiling of Segmental Gene Expression in the Epididymis Biology of Reproduction. ,vol. 73, pp. 404- 413 ,(2005) , 10.1095/BIOLREPROD.105.039719
Brigitte Ganter, Stuart Tugendreich, Cecelia I. Pearson, Eser Ayanoglu, Susanne Baumhueter, Keith A. Bostian, Lindsay Brady, Leslie J. Browne, John T. Calvin, Gwo-Jen Day, Naiomi Breckenridge, Shane Dunlea, Barrett P. Eynon, L. Mike Furness, Joe Ferng, Mark R. Fielden, Susan Y. Fujimoto, Li Gong, Christopher Hu, Radha Idury, Michael S.B. Judo, Kyle L. Kolaja, May D. Lee, Christopher McSorley, James M. Minor, Ramesh V. Nair, Georges Natsoulis, Peter Nguyen, Simone M. Nicholson, Hang Pham, Alan H. Roter, Dongxu Sun, Siqi Tan, Silke Thode, Alexander M. Tolley, Antoaneta Vladimirova, Jian Yang, Zhiming Zhou, Kurt Jarnagin, Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action. Journal of Biotechnology. ,vol. 119, pp. 219- 244 ,(2005) , 10.1016/J.JBIOTEC.2005.03.022