Maturation of functional cardiac tissue patches

摘要: Abstract: Our knowledge regarding native heart development is relatively comprehensive; however, we remain largely dependent on empiricism in our approaches to recapitulate cardiomyogenesis vitro. Toward clinical translation, it critical that understand how different biochemical, biophysical and biomaterial parameters of tissue culture govern the maturation functional output engineered myocardium, particularly when using pluripotent stem cell-based approaches. Here review processes myocardial maturation, compare them with those observed during cardiac tissues, discuss potential toward promoting We conclude by offering impressions important next steps.