作者: Robert J. Beynon
DOI: 10.1093/BIOINFORMATICS/1.2.111
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摘要: Software for non-linear curve fitting has been written in BASIC to execute on the British Broadcasting Corporation Microcomputer. The program uses direct search algorithm Pattern-search, a robust that additional advantage of needing specification function without inclusion partial derivatives. Although less efficient than gradient methods, can be readily configured solve low-dimensional optimization problems are normally encountered life sciences. In writing software, emphasis placed upon 'user interface' and making most use facilities provided by minimal configuration this system.