Spines and Mental Disorders

摘要: Mental retardation (MR) is a frequent cause of cognitive disability and often associated with spine loss or dysgenesis. Deficits in the regulation dendritic cytoskeleton affect both structure function spines synapses, they are believed to underlie and/or contribute mental some instances. The dynamic actin-rich nature pointed Rho GTPase family members as central contributors because key regulators actin dynamics organization. It therefore not surprising that mutations genes encoding effectors GTPases have been human neurological diseases. This article focuses on role their signaling molecules morphogenesis MR.