Variants of SCARB1 and VDR Involved in Complex Genetic Interactions May Be Implicated in the Genetic Susceptibility to Clear Cell Renal Cell Carcinoma
作者： Ewelina Pośpiech , Janusz Ligęza , Wacław Wilk , Aniela Gołas , Janusz Jaszczyński
DOI: 10.1155/2015/860405
关键词:
摘要: The current data are still inconclusive in terms of a genetic component involved the susceptibility to renal cell carcinoma. Our aim was evaluate 40 selected candidate polymorphisms for potential association with clear carcinoma (ccRCC) based on independent group 167 patients and 200 healthy controls. obtained were searched effects particular as well haplotypes interactions. Association testing implied position rs4765623 SCARB1 gene (OR = 1.688, 95% CI: 1.104–2.582, P 0.016) haplotype VDR comprising positions rs739837, rs731236, rs7975232, rs1544410 (P 0.012) be risk factors studied population. study detected several epistatic contributing ccRCC. Variation GNAS1 implicated strong synergistic interaction BIRC5. This effect part model suggested by multifactor dimensionality reduction method including also synergy between 0.036). Significance GNAS1-SCARB1 further confirmed logistic regression 0.041), which indicated involvement additional EPAS1 0.008) revealing interactions 0.016), MC1R 0.031), 0.032), 0.035).
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