Method for preparing aromatic or pyridine meta-fluorination compound

作者: Du Chengtang , Tao Xin , Zhuang Dongqing , Hou Tengteng , Ge Fangsun

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摘要: The invention discloses a method for preparing an aromatic or pyridine meta-fluorination compound. includes the steps that halogenated compound serves as raw materials, alkali metal fluoride fluorinated reagents, aprotic polar solvents serve reaction solvents, phase transfer catalysts are added, and is prepared through substitution reaction. defect halogen exchanging difficult can be overcome fluorination technology used in process, efficiently prepared. has advantages yield high, speed materials easy to get, material losses low, simple; suitable larges-scale industrial production.

参考文章(5)
Ralf Dr Pfirmann, Theodor Dr Papenfuhs, Process for the preparation of 2,4,5 trifluorobenzonitrile ,(1993)
Dietmar Dr. Bielefeldt, Norbert Dr. Lui, Otto Dr. Neuner, Michael Holzbrecher, Process for the preparation of 2,3,4,5-tetrafluorobenzene derivatives ,(1998)
R. Garth Pews, James A. Gall, Jack C. Little, Preparation of 3,4-difluorobenzotrifluoride ,(1988)
Lu Shuai, Wu Weibin, Wu Yongming, Wu Xiaobing, Chen Hongfu, Preparation method of hexafluorobenzene and chloropentafluorobenzene ,(2013)