The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes

摘要: Type-2 diabetes mellitus (T2DM) is a disorder that characterized by high blood glucose concentration in the context of insulin resistance and/or relative deficiency. It causes metabolic changes lead to damage and functional impairment organs tissues resulting increased morbidity mortality. this form whose prevalence increasing at an alarming rate due ‘obesity epidemic’, as obesity key risk factor development resistance. However, majority individuals who have do not develop compensatory increase secretion response demand. This adaptive sustained both β-cell function mass. Importantly, there evidence Serine/Threonine kinase mammalian target rapamycin (mTOR) plays role regulation mass therefore likely critical adaptation. Therefore, primary focus review summarize our current understanding mTOR stimulating pancreatic thus, prevention type-2 diabetes.