The Clinical Meaning of Mucin Phenotype and Epstein-Barr Virus Infection in Gastric Cancer

摘要: Background/Aims: Differentiated type adenocarcinomas producing gastric mucin are receiving much attention because of their degree clinical malignancy. Most Epstein-Barr virus (EBV)-associated cancers undifferentiated type, and correlate with mucin. We analyzed the meaning phenotypes detection EBV in cancers. Methodology: The objects study were 120 consecutive cancer lesions, resected endoscopically (EMR group, n=54) or surgically (surgery n=66). determined using immunostaining for human (HGM), MUC2, CD10. Changes histological within lesions examined. presence was situ hybridization EBV-encoded small RNA 1 (EBER-1). Results: incomplete intestinal phenotype accounted 83% EMR only 13%. None group had changes differentiation, there no EBER-1-positive lesion. In surgery 29%, significantly more than (p=0.0363). 64% lesions. differentiation common (16/66) (0/54) (p=0.0001), tending to be There 3 accounting 5%, all HGM positive. Conclusions: appears little need determine status cases where surgical resection is indicated, however, preoperative findings indicate a depth invasion SM greater, and/or an lesion, then phenotyping biopsy specimens may useful predicting predominant tumor.